ABSTRACT The 2022 SoCal Genome Stability Symposium is a one-day conference that will be held at the University of California, Irvine. In recent years, many novel cancer therapies have been developed to target DNA repair pathways. These new therapies are currently moving from the lab to the clinic, and we are poised for a rapid expansion of new DNA repair pathway-targeting drugs that will be used to eliminate different types of cancer. The conference will focus on research on genomic instability, DNA mutagenesis, environmental mutagens, DNA damage signaling, mechanisms of DNA repair, and their implications in cancers and therapies. At the conference, graduate students and postdoctoral fellows from laboratories located in Southern California working on these specific topics will present their current unpublished research. The goals and objectives of the conference are: 1) To stimulate the interactions among laboratories across Southern California working on these specific topics. The int