# Correlates of protective immunity to HCV and rational vaccine design: Admin Core

> **NIH NIH U19** · EMORY UNIVERSITY · 2023 · $93,840

## Abstract

Abstract
In this program, we propose to determine the correlates of protection in individuals that spontaneously clear
multiple HCV infection episodes. This will give highly valuable information for the design of next generation of
vaccines. Our goal to assess the role of antigen-specific T and B cell responses in infection outcome and to
generate an efficacious immune response by vaccination strategies in non-human primates based on emulating
successful resolution of natural re-exposure and re-infection in human patients.
This U19 proposal consists of 3 Projects and two Cores consisting of an Administrative Core A and a Clinical
Core B. The Administrative Core A will provide two functions: (i) provide overall administrative oversight and
support for the Program and (ii) provide biostatistical analyses and data management support for the individual
projects and Cores. This Administrative Core will be led by Dr. Grakoui at Emory University and will provide the
coordination necessary to make effective and efficient use of resources and intermediate results from this
collaborative effort. The primary function will be to facilitate scientific interactions between the Project leaders as
well as Core leaders. The administrative component will provide the leadership to ensure milestones are met,
assessment of the Core functions, modification of scientific goals, incorporation of any new collaborators,
decisions of ongoing prioritization and reallocation of resources. Critical decisions will be made in consultation
with the Project leaders and program official at NIH. The Administrative Core will file annual reports to the NIH.
The Administrative Core will maintain budgets and oversee any re-budgeting that is needed to meet program
goals. The biostatistics portion of the Administrative Core will provide data management and statistical support
for the three projects. In addition, the Biostatics portion will establish and maintain appropriate database,
management and analysis in response to investigators' requests. In order to provide services to meet the
analytical challenges the Core will include facilitating methodologies necessary for addressing complex statistical
issues encountered in various research projects. In addition, provide essential metrics between the clinicians,
scientists and biostatisticians. Having resources dedicated to the biostatistics and data management needs for
the research proposed here, will add enormous value to the quality and productivity of the research conducted
by the Investigators and to disseminate this information correctly to the scientific community.

## Key facts

- **NIH application ID:** 10608106
- **Project number:** 5U19AI159819-03
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Arash Grakoui
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $93,840
- **Award type:** 5
- **Project period:** 2021-04-15 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10608106

## Citation

> US National Institutes of Health, RePORTER application 10608106, Correlates of protective immunity to HCV and rational vaccine design: Admin Core (5U19AI159819-03). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10608106. Licensed CC0.

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