ABSTRACT Support is requested for a Keystone Symposia conference entitled Myeloid Cells: Development, Diversity and Distinct Biological Roles, organized by Drs. Gwendalyn Randolph, Minsoo Kim, Roxane Tussiwand, and Muzlifah Haniffa. The conference will be held in Snowbird, Utah from March 16-19, 2023. It is becoming more evident that myeloid cells participate critically in a variety of physiological and pathophysiological processes and that targeting myeloid cells, either at selected stages of their development or as they mature, may be successfully harnessed in the treatment of cancers or infectious disease. The application of rapidly evolving omics technologies are aiding in the quest to increase understanding of myeloid cell diversity and the potential of targeting them therapeutically. However, at the same time, fundamental questions about myeloid cell identity and function remain unknown. This Keystone Symposia conference will address these frontiers as it aims to attract speakers and attendees across the full breadth of the field. The conference program will include key talks intended to focus on the application of new technologies in the field, the advances they bring, best-practice application, and potential complications in analysis. Significant focus will also be given to the role of myeloid cells in cancer and metastasis, including the fast-growing area of how neutrophils aid tumor metastasis. Basic science that covers myeloid cell development and function will be interspersed with talks on the role of myeloid cells in disease states. In the last decades, the number of outstanding scientists in the field has grown tremendously, and this conference will showcase this growth through inclusion of many new dimensions in the field.