PROJECT SUMMARY: This application requests support for 20 Trainee Travel Awards for the Society for Basic Urologic Research (SBUR) 2022 Fall Meeting entitled, “Complex cells, systems, and regulatory pathways in urologic biology”, which will be held on November 10-13, 2022 at the JW Marriott Orlando Grande Lakes, Orlando, FL. The SBUR Fall Research Meeting has been held annually since 1992. To the best of our knowledge, this conference will be the only multi-day conference fully dedicated to basic urologic research in 2022. We have developed a strong program with topics that are current, cutting edge and relevant to the basic and translational urologic research community. Invited speakers were selected to insure subject diversity and bring together populations of investigators that will benefit from cross-talk, but may not typically interact. This year's program includes a Trainee Symposium, three keynote lectureships, five plenary sessions and one discussion session. The Leland W.K. Chung Lecturer, Elaine Fuchs, will discuss stem cells coping with stress and the AUA lecturer, Larisa Rodriguez, will discuss environmental stress in the development and maintenance of urinary symptoms, voiding dysfunction and bladder pain. Plenary session topics include 1) Cellular communication, inflammation and immunology in urologic tissue microenvironments; 2) Cellular Identify, Function, and Plasticity in Urologic Biology; 3) Modeling urologic biology and disease; and 4) Emerging Pathways, Biomarkers, and Therapeutic Targets in Urologic Disease; and 5) Post-transcriptional gene regulation in Urologic Disease. The discussion session is focused on bioinformatics and will include presentations on the emerging practices in data acquisition and analysis. The funds requested from this application will support travel awards for trainees and early career investigators, with emphasis on supporting women and investigators from groups under-represented in research. The primary goals of the conference are to: 1) highlight recent findings in the study of basic mechanisms of urologic diseases; 2) identify critical knowledge gaps in the study of urologic diseases and stimulate approaches to address them; 3) attract leading scientists from diverse fields in benign and malignant urology; 4) stimulate interactions between basic, translational and clinical research scientists from diverse backgrounds to facilitate cross-disciplinary communication and collaboration; 5) cultivate active participation of women, minorities, the disabled, trainees, and early career investigators through providing opportunities to present their research and to create pathways for their integration into the field; 6) disseminate and accelerate novel discoveries in urologic diseases; 7) provide career mentorship and networking opportunities to trainees and early career investigators through the Trainee Symposium. We anticipate a meeting attendance of >250, including SBUR members and non-members, including...