# Cannabidiol and Macrophage Chronic Inflammation in a Virally Suppressed Rhesus Macaque Model

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 2022 · $109,586

## Abstract

PROJECT SUMMARY/ABSTRACT
This project aims to understand the impact of cannabidiol on changes in gut bacterial compositions in a virally
suppressed SIV rhesus macaque model to support the training of Dr. Rosado-Franco and ultimate transition as
an independent substance abuse HIV researcher. Cannabidiol is the most abundant non-psychotropic
cannabinoid from the Cannabis plant and its studies as adjunctive anti-inflammatory therapy in people living
with HIV is of major interest. In this Diversity Supplement Proposal, we are interested in understanding if
changes in the gut bacterial abundance are linked to myeloid cell activation or by modulation of antiviral
signatures. Feces from Rhesus Macaque either healthy or infected with SIV and treated daily with cART and/or
CBD will be collected longitudinally. Genomic DNA will be extracted, and 16S and IT-S 2 genes will be
sequenced using Illumina sequencing. Differences in taxonomic profiles and alpha and beta diversity will be
determined between different groups. This will help us understand the appropriate bacterial composition for
healthier gut and brain immunity in a HIV monkey disease model. With the guidance of his mentors Drs.
Williams and Sears, his mentoring team, and the proposed training and professional development activities,
Dr. Rosado-Franco will be well prepared to submit a K01 application to NIDA in September 2023 to facilitate
his transition to independence.

## Key facts

- **NIH application ID:** 10609650
- **Project number:** 3R01DA052859-03S1
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Dionna Whitney Williams
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $109,586
- **Award type:** 3
- **Project period:** 2020-09-30 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10609650

## Citation

> US National Institutes of Health, RePORTER application 10609650, Cannabidiol and Macrophage Chronic Inflammation in a Virally Suppressed Rhesus Macaque Model (3R01DA052859-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10609650. Licensed CC0.

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