# Hyperpolarized MRI Technology Resource Center

> **NIH NIH P41** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $1,211,237

## Abstract

PROJECT SUMMARY/ABSTRACT
The overall goal of this Hyperpolarized MRI Technology Resource Center (HMTRC) renewal project is to
develop and disseminate optimal new hyperpolarized (HP) 13C MR technologies with requisite
training/documentation to advance significantly this emerging molecular imaging method driven push-pull by 13
Collaborative Projects (10 extramural). Through numerous preclinical and clinical research studies to date, it
has become clear both that HP 13C MR has outstanding research and clinical value, but also that virtually all
aspects of this technology (instrumentation, agent chemistry, DNP/dissolution methodology, MR acquisition,
and data analysis) require specialized developments to realize their full potential.
These new technologies, driven “push-pull” by the CPs, will be developed through three Technology Research
& Development (TRD) projects and provided to 12 Service Projects (10 extramural) to benefit their funded
research and disseminated widely to the general scientific community. TRD1 focuses on technology
development for polarizer and RF detector/exciter instrumentation. TRD2 will develop novel HP MR
molecular imaging probes tested in realistic preclinical models and correlative science studies. TRD3 will
develop new HP C-13 MR acquisition and free, open-source analysis software for the reconstruction, analysis,
and visualization of HP MR data specialized for CP and SP needs.
This proposed P41 renewal project was recently reviewed by our External Advisory Committee that is
comprised of experts in HP 13C MRI, clinical translation, and CP & SP PI’s. Their report states: “The EAC…is
unanimous in their assessment that the HMTRC is high functioning as an NCBIB. The HMTRC has led the
nation (and the world) in the development and translation of HP MRI through a unique combination of skills,
expertise, instrumentation, environment, clinical engagement, and industry engagement, which simply does not
exist elsewhere. The HMTRC will continue to serve as a critical national resource through the next funding
cycle as the field of HP MRI expands and matures, particularly with the clinical translation of new HP agents,
and more sites engaging in research involving human subjects. The restructured Center benefits from clear
and enhanced synergy between all TR&Ds and Collaborative Projects that are more broadly geographically
distributed. HMTRC programs for training and dissemination remain outstanding. Progress in the engagement
and stimulation of clinical interest is nothing short of remarkable, and crucial for the continuing growth and
development of this field.” The current P41 project was designed 5 years ago to focus on preclinical HP 13C
MR research, since at that time, human studies were only being conducted at UCSF. However, now that many
different sites are conducting clinical research studies with the support of this NCBIB, the new renewal P41 is
redesigned to facilitate widespread future clinical trials of HP 13C MRI to add...

## Key facts

- **NIH application ID:** 10611455
- **Project number:** 5P41EB013598-12
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Daniel B Vigneron
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $1,211,237
- **Award type:** 5
- **Project period:** 2011-08-01 → 2027-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10611455

## Citation

> US National Institutes of Health, RePORTER application 10611455, Hyperpolarized MRI Technology Resource Center (5P41EB013598-12). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10611455. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*