# New Directions in Palladium/Norbornene Cooperative-Renewal

> **NIH NIH R01** · UNIVERSITY OF CHICAGO · 2023 · $337,566

## Abstract

Abstract: We are engaged in the systematic efforts to exploit new, efficient, and broadly useful
palladium/norbornene (Pd/NBE) catalysis for site-specific arene/heteroarene vicinal di-
functionalization and one-step carbonyl 1,2-transposition. Our objectives in the proposed funding
period include first to realize a previously unprecedented ortho oxygenation of aryl halides
enabled by a new class of electrophile; second to develop direct vicinal difunctionalization of five-
membered heteroarenes via both oxidative and redox-neutral approaches; and third to enable a
one-step carbonyl 1,2-transposition reaction. The proposed research is expected to identify new
synthetic methods and efficient catalyst systems, which should provide general and distinct
approaches to access poly-substituted arenes and heterocycles commonly found in
pharmaceuticals or to efficiently relocate carbonyl groups in complex molecules for generating
novel “functional group-shifted” analogues.

## Key facts

- **NIH application ID:** 10611466
- **Project number:** 5R01GM124414-06
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Guangbin Dong
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $337,566
- **Award type:** 5
- **Project period:** 2018-06-01 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10611466

## Citation

> US National Institutes of Health, RePORTER application 10611466, New Directions in Palladium/Norbornene Cooperative-Renewal (5R01GM124414-06). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10611466. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*