Project Summary Understanding the mechanisms underlying the transition to chronic pain is key to mitigating the dual epidemics of chronic pain and opioid use in the U.S. As part of the NIH funded Acute to Chronic Pain Signatures (A2CPS) Program, we have established a Data Integration and Resource Center (DIRC) at Johns Hopkins University and collaborating institutions that works to integrate imaging, omics, behavioral, and clinical measures to develop biosignatures for the transition to chronic pain. In this administrative supplement we seek funding for an additional three-year period to continue data capture, processing, and analysis.