Abstract The Tailored Retention and Engagement for Equitable Treatment of OUD and Pain (TREETOP) clinical research center at the University of Pittsburgh was established to develop effective, equitable, and sustainable interventions for chronic pain and opioid use disorder. Its goal is to improve treatment for comorbid chronic pain and OUD, particularly among rural and Black communities which have been disproportionately impacted by the opioid epidemic. This supplement will engage previously unengaged communities within the TREETOP research program, specifically non-English speaking first-generation immigrants from the Latine and Bhutanese communities in the Pittsburgh region. It will accomplish this engagement through partnership with community organizations, and interviews investigating the experience of pain and substance use disorders in these communities; these data collection methods will also explore the use of any treatment for or means of coping with pain among members of these communities, including substance use, as well as examine any treatment and pain management needs they have. This data, as well as the relationships built in collecting it, will form the basis of a community co-designed pilot project to address pain in non-English speaking communities. The final output of the supplement will be a pilot grant proposal submitted to TREETOP, as well as methods papers outlining lessons learned from the community-engaged research process.