# Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Data Coordinating Center for VEDS

> **NIH NIH U24** · JOHNS HOPKINS UNIVERSITY · 2022 · $1,500,000

## Abstract

Project Summary/Abstract
 Nonalcoholic fatty liver disease (NAFLD) affects one in three adults and one in five children in North
America and is a growing public health issue in the United States and many parts of the world. NAFLD, and
especially nonalcoholic steatohepatitis (NASH), may lead to cirrhosis requiring liver transplant, and liver
cancer, as well as liver-, cardiovascular-, and cancer-related morbidity and mortality, resulting in increased
health burdens and associated costs. The Nonalcoholic Steatohepatitis Clinical Research Network (NASH
CRN) has been sponsored by the National Institutes of Health (NIH) since 2002 and has provided important
information regarding the natural history and treatment of NAFLD and NASH in adults and children, and has
set the stage for translational research focused on the pathogenesis, diagnosis, treatment, and clinical
management of these patients. This supplement application is in response to the Administrative Supplements
to Existing NIH Grants and Cooperative Agreements (PA-20-272) as part of our parent award Limited
Competition for the Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)
Data Coordinating Center (DCC). The DCC aims for the continuation in response to the PA are: 1) To initiate
and complete the Vitamin E dosing study (VEDS) treatment trial and 2) To provide the DCC functions
necessary to complete VEDS including: research leadership, financial management and disbursement of
per capita payments to the VEDS clinical centers, expertise in biostatistical analysis, data management,
multicenter coordination, quality control methods, safety oversight, project support, communication, and
organization. The DCC has worked productively with the clinical centers in the past and is eager to continue
its collaboration with the clinical centers as well as with NIDDK program staff, to complete these important
research objectives. The NASH CRN is poised to continue its major impact on the field and directly advance
the mission of the National Institutes of Health to improve the health of the public.

## Key facts

- **NIH application ID:** 10616124
- **Project number:** 3U24DK061730-20S1
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** James A Tonascia
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,500,000
- **Award type:** 3
- **Project period:** 2002-05-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10616124

## Citation

> US National Institutes of Health, RePORTER application 10616124, Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Data Coordinating Center for VEDS (3U24DK061730-20S1). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/10616124. Licensed CC0.

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