PROJECT SUMMARY / ABSTRACT Precision emergency medicine is the purposeful use of big data and technology to safely, efficiently, and authentically deliver acute care for individual patients and their communities. This approach builds upon the foundation of precision medicine, in which clinical decisions are tailored to individual patients through the application of genomic, biological, environmental, and public health data. In this model, emergency physicians can leverage many emerging sources of patient data derived from technologies such as wearable and implantable devices, -omics, rapid point-of-care testing, and community-based and public health databases. Machine learning and other artificial intelligence can strengthen analyses of these data and improve the accuracy of clinical decision-making. The use of technology, multi-source data, and analyses contextualized to the local community can paint a clearer picture of the whole person and individually tailor emergency care to their specific needs. Taken together, the adoption of precision medicine principles would represent a paradigm shift in emergency medicine towards technology-enhanced, data-driven, higher quality, individualized care. However, most emergency providers are unfamiliar with these new data sources, how to interpret them, and how to modify their clinical practices accordingly. Research is needed to understand how to best implement precision emergency medicine in an effective and equitable manner. In the 2023 Society for Academic Emergency Medicine (SAEM) Consensus Conference, Precision Emergency Medicine: Setting a Research Agenda, we will convene experts and thought leaders from academia and the technology sector to examine the key catalysts of precision emergency medicine, identify implementation challenges, and develop an actionable 10-year research agenda with relevant patient-centered outcomes. SAEM consensus conferences are annual, one-day scientific meetings that have successfully used a consensus-building approach to craft research agendas for groundbreaking and important topics in emergency medicine for over 20 years. The proposed SAEM consensus conference will introduce precision emergency medicine as a conceptualization of translational science that results in specific, timely, patient-centered, emergency care. Our conference outcomes will stimulate further research to examine precision emergency medicine as a safer, higher-quality, more accessible, and more equitable clinical care paradigm than current practices. To accomplish these goals, we will host a methodologically rigorous consensus conference that will meet the following aims: (1) develop a shared mental model of precision emergency medicine, (2) establish a research agenda for precision emergency medicine for the next decade, and (3) identify educational gaps that must be addressed for emergency providers.