# Modulating Fibro/Adipogenic Precursors to Prevent Adipogenic Replacement of Muscle

> **NIH NIH K01** · CHILDREN'S RESEARCH INSTITUTE · 2023 · $99,342

## Abstract

ABSTRACT.
Successful muscle regeneration requires an elaborate cellular choreography between multiple
cell populations to remove and replace damaged fibers. Disruption of this choreography leads to
muscle degeneration and fibrotic or adipogenic replacement of myofibers. This phenomenon is
particularly prevalent in muscular dystrophies, where progressive muscle loss leads to severe
debilitation and early loss of life. Hence, there is growing need to understand the cell
populations and their interactions which contribute to myofiber regeneration, but can lead to
fibrotic or adipogenic replacement when gone awry. This project aims to understand the
mechanism underlying impaired cellular interactions leading to myofiber loss and muscle
weakness in limb girdle muscular dystrophy type 2B and test approaches to prevent this
impairment. This understanding will help develop novel targeted therapeutic approaches to
arrest disease progression in this and other muscular dystrophies that are currently without
effective treatment options.

## Key facts

- **NIH application ID:** 10617817
- **Project number:** 5K01AR077686-03
- **Recipient organization:** CHILDREN'S RESEARCH INSTITUTE
- **Principal Investigator:** Marshall Hogarth
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $99,342
- **Award type:** 5
- **Project period:** 2021-05-21 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10617817

## Citation

> US National Institutes of Health, RePORTER application 10617817, Modulating Fibro/Adipogenic Precursors to Prevent Adipogenic Replacement of Muscle (5K01AR077686-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10617817. Licensed CC0.

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