# Center for Microbial Pathogenesis and Host Inflammatory Responses

> **NIH NIH P30** · UNIV OF ARKANSAS FOR MED SCIS · 2023 · $1,140,000

## Abstract

PROJECT SUMMARY/ABSTRACT
 The Center for Microbial Pathogenesis and Host Inflammatory Responses (CMPHIR: P20-GM103625) was
established at the University of Arkansas for Medical Sciences (UAMS) in 2012. The underlying scientific theme
is that addressing existing and emerging problems in infectious disease in a clinically relevant fashion will require
an understanding of both the pathogens themselves and how they impact the host immunological and
inflammatory response. This theme is based on the premise that understanding the complex interplay between
diverse pathogens and their common human host is a prerequisite to maximizing opportunities to manipulate
one or both sides of this equation in favor of the desired prophylactic and/or therapeutic outcome. In Phases I
and II, we assembled a critical mass of investigators around this scientific theme and provided them with the
administrative and technical resources they needed to establish successful scientific careers. In Phase III, we
will refine and expand on these efforts with the overall goal of building on our success in Phases I and II to
establish a self-sustaining Center of Biomedical Research Excellence that focuses on infectious diseases in a
comprehensive and clinically relevant fashion. To this end, the specific aims of this Phase III application are to:
1) provide an infrastructure that maximizes the competitiveness of CMPHIR investigators through the support of
essential core facilities; 2) promote continued growth of the CMPHIR and career development of its investigators;
and 3) transition the CMPHIR to a nationally recognized, self-sustaining Center of Biomedical Research
Excellence with the expertise and resources to address existing and emerging problems in infectious disease.

## Key facts

- **NIH application ID:** 10618372
- **Project number:** 5P30GM145393-02
- **Recipient organization:** UNIV OF ARKANSAS FOR MED SCIS
- **Principal Investigator:** MARK S SMELTZER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $1,140,000
- **Award type:** 5
- **Project period:** 2022-05-05 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10618372

## Citation

> US National Institutes of Health, RePORTER application 10618372, Center for Microbial Pathogenesis and Host Inflammatory Responses (5P30GM145393-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10618372. Licensed CC0.

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