# Examining Trauma Prevalence and Exploring Interoception as a Mechanism of Emotion Regulation in MOUD

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2022 · $174,721

## Abstract

Project Abstract
The Parent Grant (R01 AT10742; PIs Price & Merrill) is a two-group randomized controlled trial, with repeated
measures, designed to enroll a sample of 330 in medication treatment for opioid use disorder (MOUD) to
assess the effectiveness of Mindful Awareness in Body-oriented Therapy (MABT) as an adjunct to medication
treatment for opioid use disorder (MOUD). The national opioid epidemic requires development of real-world
evidence-based treatments for opioid use disorder, including adjuncts to MOUD. Interventions are needed that
address the complex needs of patients with opioid use disorder, which include substantial mental health co-
morbidity (e.g. PTSD, depression) and high rates of chronic pain. MABT, a novel mindfulness-based
intervention, uniquely addresses aspects of awareness, interoception, and regulation that may be associated
with pain, mental health distress, and behavioral control that increase risk of relapse and poor treatment
outcomes. The proposed Diversity Supplement examines two critical additional research questions. The aims
are: 1) to describe the types of lifetime exposure to trauma and compare types of trauma exposure between
men and women engaged in MOUD, and to examine the relationship between types of trauma exposure and
symptomatic distress in this sample at baseline; and 2) to explore the underlying mechanisms of MABT by
examining interoceptive awareness as a possible mediator of emotion regulation difficulties and other
indicators of mental health distress. It is hypothesized that emotion regulation difficulties in MABT + TAU
compared to TAU only will be mediated by increased interoceptive awareness from baseline to 3-month follow-
up. This application thus addresses key gaps in knowledge that are important for consideration in MOUD
treatment that may be critical for reducing relapse and improving treatment outcomes.

## Key facts

- **NIH application ID:** 10618645
- **Project number:** 3R01AT010742-01S1
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** JOSEPH O MERRILL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $174,721
- **Award type:** 3
- **Project period:** 2019-09-28 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10618645

## Citation

> US National Institutes of Health, RePORTER application 10618645, Examining Trauma Prevalence and Exploring Interoception as a Mechanism of Emotion Regulation in MOUD (3R01AT010742-01S1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10618645. Licensed CC0.

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