Role of novel VTA neurons in addiction-related behaviors

NIH RePORTER · NIH · R01 · $55,879 · view on reporter.nih.gov ↗

Abstract

PROJECT SUMMARY Thveenttreaglmeanrtea(alVTiAsa)corceomponoeftnhtneeurcailrctuhidatrtriygvoe-asdlirebcetheadvior andaprimtaarrygtehtrowuhgihcdhruogfsabusmeodulbaetheavAilotrh.oguegnherraelglayradsaed dopaminneurcglieacubsoh,uatolfVTAneursoingstnharlorueglheoaftsheaeminaocindeurotransmi GABaAngdlutaTmhaetnsee.uraornaeslstoargoefdtrsuogfasbubsuemtuclhesstudRieecde.envtidence froomulraabndothehrasbsegutnoshotwhalti,VkTeADAneuroancst,iivnViTtAGyABAandglutamat neurcoanpnsrofosuhnadmploeytivbaetheadvFiuortsh.esrumbo-rpeo,puolfVaTtAnieounrsroenlsemaosree thaonneofthetsherreeecycling neurtohncsaot-reldeopaasmeaindelutamoarte, transmitters, including glutaamnaGdtAeBAT.hgeoaolftshpirsopoasrtaeoildenhtoiwtfryanscmiot-trefrlreoaVmsTeAcontribut tothperoceusnsdeesrbleyhianvgrieoirnaflonrtac,nehdmoewco-relneeausrifonungnsctiionntaelgilrnyattoe thmeesolinmebuirccailrctuhiratetsgumloattievbaetheadvWieowriu.lslaenarroafgyeneatpipcroaicnhes combinwaittibhoenhaviaonraatlo,maincdealle,ctrophyassisoailynomsgiictceoaslelectpirvoebtlehye connecatnidfvuintcytoifdoinscVrTeAtceircuits.thicsntinruisnegarch cpormopgrriaasmes Together thoropulgathnodeftihnfeoramnfduncotfnioovncellasosfVeTsAneuraonedsnhanocuuernderstand ofhowintrViTnAhseitcerogsehnaepbieetshyaviorstoneuropsydcihsieaatsrei.c relevant

Key facts

NIH application ID
10619222
Project number
3R01DA036612-09S1
Recipient
UNIVERSITY OF CALIFORNIA, SAN DIEGO
Principal Investigator
Thomas Hnasko
Activity code
R01
Funding institute
NIH
Fiscal year
2022
Award amount
$55,879
Award type
3
Project period
2014-04-01 → 2023-02-01