# Defining the genomic and microenvironmental features of diffuse large B cell lymphoma in HIV + patients (Biospecimens/Biocohort)

> **NIH NIH P30** · DUKE UNIVERSITY · 2022 · $83,333

## Abstract

ABSTRACT
HIV-positive patients are at high risk for developing diffuse large B cell lymphoma (DLBCL). Despite improved
patient outcomes in the era of retroviral therapy, HIV-positive DLBCL patients continue to experience inferior
survival compared to their HIV-negative counterparts. While the genetic origins and prognostic factors of DLBCL
are increasingly well-defined, a similar understanding of the disease in HIV+ patients has been elusive. We have
carried out a preliminary genomic analysis of HIV+ DLBCL patients that revealed key differences in mutation
patterns. Additionally, we found differences in a previously described gene expression signature that reflects the
tumor microenvironment and is strongly associated with poor survival. In this proposal, we seek to advance our
understanding of the genetic and microenvironment features underlying DLBCL in HIV+ patients, particularly as
they relate to outcome. Through a combination of genomics approaches in a well-powered patient cohort, we
will comprehensively define the genetic alterations, gene expression patterns and microenvironment
characteristics that distinguish HIV+ DLBCLs. This work will provide an important resource for the field and
indicate therapeutic targets to improve outcomes in this disease, including approaches to disrupting the nexus
between the tumor and the microenvironment.

## Key facts

- **NIH application ID:** 10619709
- **Project number:** 3P30CA014236-48S2
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Michael B Kastan
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $83,333
- **Award type:** 3
- **Project period:** 2022-01-01 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10619709

## Citation

> US National Institutes of Health, RePORTER application 10619709, Defining the genomic and microenvironmental features of diffuse large B cell lymphoma in HIV + patients (Biospecimens/Biocohort) (3P30CA014236-48S2). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10619709. Licensed CC0.

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