# HIV Redirecting Innate Immunity by Vpu Targeting of JAK1

> **NIH NIH R03** · WESTERN UNIVERSITY OF HEALTH SCIENCES · 2023 · $71,500

## Abstract

Project Summary/Abstract
It is well known that the pathogenesis of HIV is intricately linked to the immune system. For HIV to promote its
replication and long-term infection HIV must also modulate cytokine signaling to manipulate the immune
microenvironment HIV is existing in. In our previous work we have found that HIV has encoded accessory
genes that are able to block the action of the important innate antiviral cytokine named Type I Interferon. Type
I Interferons were named for their ability to interfere with the replication of viruses and HIV has encoded
multiple ways to block this cytokine. The overall goal of this R03 application is to determine how one of the
HIV-encoded genes that blocks Type I Interferon can block this signaling in T cells, the major cell infected by
HIV. Long term, this work is critical to set the stage to better understand how HIV sustains itself in a person
and avoids elimination by the innate immune system.

## Key facts

- **NIH application ID:** 10619889
- **Project number:** 1R03AI172631-01A1
- **Recipient organization:** WESTERN UNIVERSITY OF HEALTH SCIENCES
- **Principal Investigator:** DAVID JESSE SANCHEZ
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $71,500
- **Award type:** 1
- **Project period:** 2023-06-20 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10619889

## Citation

> US National Institutes of Health, RePORTER application 10619889, HIV Redirecting Innate Immunity by Vpu Targeting of JAK1 (1R03AI172631-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10619889. Licensed CC0.

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