Project Summary The Parent Grant, the UNM IMPOWR Center (University of New Mexico Integrative Management of chronic Pain and Opioid use disorder for Whole Recovery; RM1DA055301; mPIs Witkiewitz, Pearson), seeks to utilize a holistic approach to assess and treat biopsychosocial factors that contribute to pain and opioid use disorder (OUD), and improve the lives of diverse individuals with chronic pain and opioid misuse/OUD in diverse communities. UNM IMPOWR has two major research projects. The HOPE Trial is a multisite effectiveness- implementation trial investigating the effectiveness of an integrated treatment for chronic pain and OUD (Acceptance and Commitment Therapy [ACT] and Mindfulness-Based Relapse Prevention [MBRP]). The OPTIC Trial uses community-based participatory research (CBPR) methods to develop a culturally centered intervention for chronic pain and OUD in American Indian/Alaska Native primary care clinics based on Native American Motivational Interviewing. UNM IMPOWR has also convened a community advisory board and scientific advisory board to help guide program development, implementation, and to maximize research impact. The research aims of the diversity supplement are to 1) begin the process to culturally center two integrated treatments for chronic pain and opioid use disorder (Acceptance and Commitment Therapy and Mindfulness-Based Relapse Prevention) for Hispanic/Latino/a/x individuals in the United States; 2) examine acceptability, feasibility, and compliance rates of an ecological momentary assessment study of pain, cognitive defusion, craving, mindfulness, and distress tolerance ; and 3) evaluate the degree of within- and between- subject variability in constructs of interest including pain, cognitive defusion, craving, mindfulness, and distress tolerance. The training aims of the supplement are to 1) acquire training in community-based participatory research; 2) acquire training in psychosocial treatments for opioid use disorder; 3) obtain experience in advanced quantitative approaches for longitudinal and intensive longitudinal data; 4) receive training in qualitative research methods and qualitative data analysis; and 5) receive training in manuscript production, research dissemination (e.g., posters, symposia), writing NIH grant applications, and the responsible conduct of research. Ultimately, the overall training and research experiences will prepare Dr. Schwebel to become a successful independent researcher examining chronic pain and OUD.