# Administrative Diversity Supplement- Novel Nano-Vaccine Technology for Inducing Immunity Against Gliomas

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $84,667

## Abstract

Gliomas are highly aggressive brain tumors and complete tumor resection is not achievable as residual tumor
cells routinely infiltrate the surrounding functional brain tissue and are protected by the blood brain barrier (BBB).
The BBB presents a significant obstacle for effective delivery of therapeutic agents to the central nervous system.
The BBB forms a highly selective semipermeable border that prevents solutes in the circulating blood from
crossing into the intracranial environment. Thus, there is an urgent need for new approaches for drug delivery
through the BBB to gliomas. To address these major unmet medical needs, here we propose to develop new
nanoparticles for delivering STING agonist to gliomas. We will develop nanoparticles that can be tuned with
different targeting moieties and effectively delivered to gliomas; elicit anti-tumor immune response by converting
the “cold” glioma tumors to “hot” tumors; eradicate established gliomas; and generate sustained anti-gliomas
immunity. This Supplement application focuses on applying the knowledge gained from the parent R01 grant to
target STING agonists to gliomas and achieve anti-tumor immunity against gliomas. Therefore, this represents
a new and complementary research component that directly relates to original goals of the grant and broadens
its translational potential and application.

## Key facts

- **NIH application ID:** 10622660
- **Project number:** 3R01NS122536-02S1
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Maria G Castro
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $84,667
- **Award type:** 3
- **Project period:** 2021-07-15 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10622660

## Citation

> US National Institutes of Health, RePORTER application 10622660, Administrative Diversity Supplement- Novel Nano-Vaccine Technology for Inducing Immunity Against Gliomas (3R01NS122536-02S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10622660. Licensed CC0.

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