# Spatial and temporal control of Rho family GTPases

> **NIH NIH R35** · UNIVERSITY OF CHICAGO · 2023 · $446,882

## Abstract

This proposal focuses on dissecting of the molecular mechanisms involved in the
control of cell division, cell polarization, and morphogenesis. These simultaneously
interrelated and functionally distinct processes are controlled by small GTPases, switch
like proteins that primarily act at cell membranes to remodel cellular physiology. These
proteins perform numerous functions in cells and tissues and their activity is highly
regulated. We propose to study the role of several small GTPases during these
processes in intact model organisms, including the nematode C. elegans and the fruit
fly, Drosophila using a combination of live cell imaging, classical genetics, and
optogenetics. We will also dissect the mechanisms responsible for the spatial and
temporal activation of these GTPases which is critical for cell division, cell polarization,
and morphogenesis. Given the high degree of conservation of these processes,
information gained in this project could aid our understanding of certain cancers and the
origin of some birth defects.

## Key facts

- **NIH application ID:** 10622772
- **Project number:** 2R35GM127091-06
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Michael A. Glotzer
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $446,882
- **Award type:** 2
- **Project period:** 2018-08-01 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10622772

## Citation

> US National Institutes of Health, RePORTER application 10622772, Spatial and temporal control of Rho family GTPases (2R35GM127091-06). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10622772. Licensed CC0.

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