# African Bi-Costal (ABC) Cancer Study

> **NIH NIH U54** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2022 · $124,539

## Abstract

ABSTRACT
This application is being submitted in response to the Notice of Special Interest (NOSI} identified as NOTCA-
22-036. The applicant parent grant is the Florida-California Cancer Research, Education &
Engagement (CaRE2
} Health Equity Center at the University of Southern California (MPls: Dr. John
Carpten and Dr. Mariana Stern). The CaRE2 Health Equity Center was established in 2018 through
funding from the NIH/National Cancer Institute (NCI} collaborative partnership among University of Florida,
Florida A&M University and University of Southern California. This bi-coastal center focused on
translational disparities research among heterogeneous minority populations focusing on cancers
known for high mortality, with the long-term goal of reducing cancer disparities in Blacks and Latinos and
training and increasing the pool of underrepresented Black and Latino scientists conducting health disparity
research. To achieve this the CaRE2 Center supports innovative translational research projects focused on
understanding the biological basis of disparities in Black and Latino populations, capturing the
wide heterogeneity within these two groups, with a foundational project focusing on prostate cancer
(one full, one pilot).
This supplement award application focuses on strengthening the capacity of an African early stage
investigator (ESI} to conduct high-quality research in sub-Saharan Africa and to generate contextappropriate
evidence to address the burden of CaP in that region. This is with the aim of providing highquality
mentored translational cancer research to an African ESI and support the training of the ESI
in developing professional competencies needed to establish a successful research career. To
achieve this, we have worked with Dr Benson Nyambega {the ESI) to research project on
investigating the Biological Determinants of Quality of Life Among Prostate Cancer SuNivors in Kenya and
Nigeria. This research is built on the existing Molecular Biology and Clinical Biochemistry skills possessed
by the ESLI with specific aims of (1) investigating Psychoneurological Symptom Cluster <PSC} classes in
Kenyan and Nigerian CaP survivors and establishing the associations between classes pf this cluster and
health-related quality of life <HROoL}. This rests on the hypothesis that there are within-group differences in
the PSC among Black CaP survivors. The hypothesis will be investigated using the European Organization
for Research and Treatment of Cancer Quality of Life Core (QoL) Questionnaire; and (2) estimating the
biological determinants fallostatic load. genetic variation of Hypothalamic-Pituitary-Adrenal <HPA} axis. and
tryptophan-kynurenine pathway metabolites} of mental health in Kenyan and Nigerian cohorts. This aim will
test the hypothesis that the level of allostatic load, genetic variation in HPA axis genes, and
kynurenine/tryptophan ratio vary by nativity and geography among Black CaP survivors and that their levels
are associated with...

## Key facts

- **NIH application ID:** 10623044
- **Project number:** 3U54CA233465-05S1
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** JOHN D. CARPTEN
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $124,539
- **Award type:** 3
- **Project period:** 2018-09-19 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10623044

## Citation

> US National Institutes of Health, RePORTER application 10623044, African Bi-Costal (ABC) Cancer Study (3U54CA233465-05S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10623044. Licensed CC0.

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