# Mechanism of nerve growth factor driven axon plasticity

> **NIH NIH R56** · TEMPLE UNIV OF THE COMMONWEALTH · 2022 · $396,250

## Abstract

PROJECT SUMMARY/ABSTRACT
 Axon plasticity, in the form of the generation of axon branches, is fundamental to the
development and repair of neuronal circuitry. In this project we will address the main hypothesis that
the intra-axonal glycolytic pathway is required for the formation and maintenance of axon branches in
vitro and in vitro. Live imaging approaches, molecular manipulations, pharmacology and optogenetic
ablation of glycolytic enzymes will be used to determine the role of the glycolytic pathway. The project
will also address the link between the glycolytic pathway and the cytoskeletal remodeling underlying
axon branching.

## Key facts

- **NIH application ID:** 10626679
- **Project number:** 1R56NS128049-01
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **Principal Investigator:** GIANLUCA GALLO
- **Activity code:** R56 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $396,250
- **Award type:** 1
- **Project period:** 2022-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10626679

## Citation

> US National Institutes of Health, RePORTER application 10626679, Mechanism of nerve growth factor driven axon plasticity (1R56NS128049-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10626679. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*