# Enhancing Sensorimotor Integration Using a Neural Enabled Prosthetic Hand System

> **NIH NIH R01** · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · 2023 · $634,078

## Abstract

PROJECT SUMMARY
 There is a large and growing population of amputees whose needs are not being fully met by current
prosthetic hand technology, which results in reduced quality of life. The long-term goal of the proposed work is
based on the notion that prosthetic hand technology that can provide task-related sensations to the residual limb
of an amputee will increase their proficiency in sensorimotor tasks and therefore allow them to participate in a
greater range of employment and leisure activities.
 The Adaptive Neural Systems neural-enabled prosthetic hand (ANS-NEPH) system was designed and
developed by our lab in collaboration with industrial and clinical partners to provide amputees with task-relevant
sensations. The system uses signals derived from sensors on an instrumented prosthetic hand to elicit sensations
by delivering stimulation via fine-wire longitudinal intrafascicular electrodes (LIFEs) implanted in peripheral
nerves of the residual limb. A commercially proven neural stimulation technology from Cochlear Ltd. was re-
engineered to interface with neural structures in the peripheral nerves with LIFEs.
 In the proposed project, we will continue a longitudinal first-in-human clinical trial to evaluate clinical safety
and device functionality Four subjects will be enrolled to participate in this long-term study. Each subject will
have the implanted components surgically installed, be fitted with the external components of the system,
participate in an extensive series of experiments designed to assess long-term viability of our approach, and use
it on a daily basis as their primary prosthetic hand.
 The primary outcome of this work will be a demonstration of clinical feasibility of a neural-enabled prosthetic
hand system for daily use at home (for approximately two years) or at the workplace that uses wirelessly-
controlled implantable stimulation technology. For transradial amputees, real-time sensation is likely to improve
sensorimotor capabilities; everyday use is likely to enhance embodiment of the prosthesis by the user.
Furthermore, stimulation of afferent fibers may also reduce the severity and incidence of phantom limb pain.
This system will constitute the next generation of prosthetic hand technology for transradial amputees and will
form the foundation for systems to be developed that can provide sensation to other upper limb amputees
(transhumeral, shoulder disarticulation). Finally, the deployment and chronic use of an implantable system that
enables stimulation of discrete sets of small groups of afferent fibers may pave the way for future uses of this
technology to activate peripheral nerves that may influence metabolic processes, enhance immune system
function, regulate gastrointestinal activity, or treat a variety of medical conditions.

## Key facts

- **NIH application ID:** 10626988
- **Project number:** 5R01EB023261-04
- **Recipient organization:** UNIVERSITY OF ARKANSAS AT FAYETTEVILLE
- **Principal Investigator:** JAMES J. ABBAS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $634,078
- **Award type:** 5
- **Project period:** 2019-03-01 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10626988

## Citation

> US National Institutes of Health, RePORTER application 10626988, Enhancing Sensorimotor Integration Using a Neural Enabled Prosthetic Hand System (5R01EB023261-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10626988. Licensed CC0.

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