# Diversity Supplement to R35 - Mechanistic Elucidation and Targeted Therapy of Organ Injury and Inflammation following Trauma

> **NIH NIH R35** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $99,051

## Abstract

Project Summary/Abstract from the Parent Grant (R35 to Matthew Neal): Multiple organ dysfunction 
syndrome (MODS) is a leading cause of death after severe trauma, which is a leading cause of mortality 
worldwide. MODS is thought to be a consequence of a vicious cascade of excessive inflammation and 
coagulation abnormalities but remains incompletely understood. The overarching goal of our research is to 
understand how trauma leads to organ injury through inflammation and clotting of blood vessels, or 
immunothrombosis. Our research focus is the central role of platelet function in driving immunothrombosis 
after trauma. We propose to tackle the following key knowledge gaps in the field: 
1) Understand the cellular mechanisms leading to micro-thrombotic organ injury in survivors after trauma
2) Unravel the immune and inflammatory consequences of modern trauma resuscitation
3) Design targeted interventions for post-traumatic organ injury and thrombosis
Project Summary/Abstract for the Diversity Research Supplement: The career development focus of this 
diversity research supplement is to foster the continuous effort of inclusion of faculty from under represented 
groups by increasing diversity in the Department of Surgery at the University of Pittsburgh and the University 
of Pittsburgh Medical Center. Dr. Mota Alvidrez as a Hispanic junior faculty member is a perfect candidate for 
this supplement as a very promising physician scientist that brings his expertise to this research team. His 
inclusion as a diverse individual will also focus in developing further his expertise in platelet biology/function, 
immunothrombosis and endothelial damage using state of the art microfluidic system assessment. Inclusion 
of Dr. Mota Alvidrez as faculty in our department aims to foster the success of the project but also by 
increasing diversity in faculty appointments particularly by the addition of highly determined and strong-driven 
individuals as Dr. Mota Alvidrez. The research supplement aims to develop Dr. Mota Alvidrez independent 
research program by growing the mechanisms outlined in the parent grant with his own independent research 
development plan. He has an amazing mentoring team with an outlined 5-year plan that will allow ample time 
for faculty development, data analysis, mentoring and grantsmanship for him to secure independent funding 
to build his research program and laboratory.
The proposed research supplement for Dr. Mota Alvidrez will focus on expanding the scope of the key 
challenges in the parent grant outlined above. The scientific scope will add novel hypothesis-driven 
experimental studies from the exciting preliminary plan from Dr. Mota Alvidrez to promote the development of 
his independent research program focusing in immunothrombosis. Dr. Mota Alvidrez research will fill 
knowledge gaps in the field of immunothrombosis in trauma while advancing the needle in post-injury care. 
He proposes to study deeper into the endothelial ...

## Key facts

- **NIH application ID:** 10627526
- **Project number:** 3R35GM119526-07S1
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Matthew D Neal
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $99,051
- **Award type:** 3
- **Project period:** 2016-09-01 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10627526

## Citation

> US National Institutes of Health, RePORTER application 10627526, Diversity Supplement to R35 - Mechanistic Elucidation and Targeted Therapy of Organ Injury and Inflammation following Trauma (3R35GM119526-07S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10627526. Licensed CC0.

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