# Protocol Review and Monitoring System

> **NIH NIH P30** · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2023 · $159,308

## Abstract

Abstract Protocol Review and Monitoring System
The City of Hope Comprehensive Cancer Center (COHCCC) Protocol Review and Monitoring System (PRMS)
has developed a two-stage review system for the review, oversight and support of cancer research conducted
by its investigators. This review system includes a first stage review by (1) Multidisciplinary Disease and Modality
Teams (DT/MT) for concept review and endorsements; followed by a second stage review by (2) the Protocol
Review and Monitoring Committees (PRMC) which include the Cancer Protocol Review & Monitoring Committee
(CPRMC) and the Biospecimen and Data Review Committee (BDRC). The offices that administratively support
the DT/MT and the PRMC are within the Clinical Trials Office (CTO) and Clinical Research Protections (CRP)
Office, respectively.
During its first and second stage reviews, the PRMS is focused on the scientific merit of protocols, prioritization
and feasibility of trial completions, as well as the oversight of the progress of approved research and termination
of any research that no longer meets those criteria. All proposed cancer clinical research must initially be
endorsed by a multi-disciplinary DT/MT and reviewed and approved by the PRMC and reviewed by the PRMC
for scientific progress on at least an annual basis. The PRMC has the authority to close trials that do not
demonstrate scientific progress and appeals are evaluated by the Committee. The BDRC was launched in April
2021 to support an enterprise-wide, efficient, and centralized scientific, prioritization, and feasibility review
process for research involving only the use of tissue and/or data. The BDRC follows the same review processes
as the CPRMC and first stage review is required.
The PRMS received full approval from the National Cancer Institute (NCI) in 2017.

## Key facts

- **NIH application ID:** 10628584
- **Project number:** 2P30CA033572-40
- **Recipient organization:** BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- **Principal Investigator:** Erminia Massarelli
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $159,308
- **Award type:** 2
- **Project period:** 1997-08-01 → 2027-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10628584

## Citation

> US National Institutes of Health, RePORTER application 10628584, Protocol Review and Monitoring System (2P30CA033572-40). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10628584. Licensed CC0.

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