# Upgrading infectious disease research facilities at University of Louisville RBL

> **NIH NIH G20** · UNIVERSITY OF LOUISVILLE · 2022 · $1,219,669

## Abstract

PROJECT SUMMARY
The University of Louisville Regional Biocontainment Laboratory (RBL) is an operational unit of the University’s
Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM). The CPM operates the
only Biosafety Level 3 laboratories and animal research facilities available to researchers in the Commonwealth
of Kentucky. We request support from NIAID through this proposal for additional facility related upgrades and
modernization of research equipment. In this administrative supplement we are not proposing any new specific
aims. First, we shall repair, renovate and modernize specific RBL building systems to enhance functions of the
research facilities. In this administrative supplement we shall replace the end of life Continuum building access
controls system with a Lenel system that meets our layered security access controls requirements. The building
chillers, necessary for maintaining appropriately conditioned air to the laboratories and vivaria will have critical
components that are near end of life replaced. The building air compressors are critical to the facility’s HVAC
controls systems, and must be replaced. Secondly, we propose to enhance and modernize the CPM in vivo
research facilities. In this administrative supplement we shall achieve our second aim by augmenting our in vivo
research capabilities with new CT/PET imaging equipment that will allow fine granularity of data acquisition,
improving our understanding of infectious disease, and assisting in discovery of vaccines and therapeutics
against biothreats and emerging infectious diseases. This equipment achieves major goals of humane in vivo
research: more comprehensive and detailed information about the infectious disease model and effect of
therapy, closely linked with reduction in the number of research subjects necessary for comprehensive
assessment of the treatment efficacy. The facility and equipment upgrades will modernize our research
infrastructure, enhancing the CPM RBL capabilities to rapidly develop and assist in deployment of
countermeasures to mitigate the effects of biothreats and emerging infectious diseases.

## Key facts

- **NIH application ID:** 10631406
- **Project number:** 3G20AI167407-01S1
- **Recipient organization:** UNIVERSITY OF LOUISVILLE
- **Principal Investigator:** KENNETH E PALMER
- **Activity code:** G20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,219,669
- **Award type:** 3
- **Project period:** 2022-08-22 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10631406

## Citation

> US National Institutes of Health, RePORTER application 10631406, Upgrading infectious disease research facilities at University of Louisville RBL (3G20AI167407-01S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10631406. Licensed CC0.

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