# Membrane properties of the OHC system

> **NIH NIH R01** · YALE UNIVERSITY · 2023 · $672,389

## Abstract

Project Summary
In this proposal we hope to build on our efforts defining the cryoEM structure of prestin, the OHC lateral wall
motor responsible for cochlear amplification, in the depolarized and contracted state. In this proposal we seek to
define the protein's structure in the expanded state brought about by voltage. We will use complementary
methods to determine its structure exploiting recent advances in image processing and using temperature and
mutations that affect its violtage sensitivity. In addition, we will also be using modeling using molecular dynamics
simulations to understand its structure under voltage control.

## Key facts

- **NIH application ID:** 10632052
- **Project number:** 5R01DC016318-07
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** DHASAKUMAR S NAVARATNAM
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $672,389
- **Award type:** 5
- **Project period:** 2017-06-12 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10632052

## Citation

> US National Institutes of Health, RePORTER application 10632052, Membrane properties of the OHC system (5R01DC016318-07). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10632052. Licensed CC0.

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