# 600 MHz NMR spectrometer with 1.7mm micro-cryoprobe

> **NIH NIH S10** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2023 · $1,802,603

## Abstract

Project Summary/Abstract
This application requests funding to purchase a new Bruker Avance NEO 600 MHz solution
state NMR spectrometer with a 1.7 mm triple resonance micro-cryoprobe and a 60 place sample
changer. The instrument will replace a defunct 600 MHz spectrometer that has been used for 15
years to develop and advance research programs in marine natural products discovery and
biosynthesis, structural biology, drug design and synthesis, metabolomics, and systems biology.
These research programs have discovered new drug leads, revealed new methods of
synthesizing complex molecules, and aim to identify markers of human disease, and
quantitatively describe life at the cellular level. NMR is essential to these projects and the
requested instrument will restore the availability of instrument time. For the mass-limited
samples these researchers deal with, a 1.7 mm micro-cryoprobe is essential as no other
commercially available probe offers comparable mass-sensitivity. Furthermore, the inclusion of a
sample changer with the requested instrument will enable research programs to expand into
high throughput omics scale research.

## Key facts

- **NIH application ID:** 10632726
- **Project number:** 1S10OD032266-01A1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Brendan Michael Duggan
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $1,802,603
- **Award type:** 1
- **Project period:** 2023-09-01 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10632726

## Citation

> US National Institutes of Health, RePORTER application 10632726, 600 MHz NMR spectrometer with 1.7mm micro-cryoprobe (1S10OD032266-01A1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10632726. Licensed CC0.

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