# Harnessing single cell epigenome-wide profiling of myeloid cells to compare and contrast Alzheimer's from HIV-associated cognitive dysfunction

> **NIH NIH R01** · WEILL MEDICAL COLL OF CORNELL UNIV · 2022 · $63,017

## Abstract

PROJECT SUMMARY/ ABSTRACT (for Alina Pang (Ndhlovu): R01 AG063846-01A1
Supplement Application)
In this application, we seek a diversity research supplement to parent award “HARNESSING SINGLE CELL
EPIGENOME-WIDE PROFILING OF MYELOID CELLS TO COMPARE AND CONTRAST ALZHEIMER'S
FROM HIV-ASSOCIATED COGNITIVE DYSFUNCTION” (AG063846-01A1). The parent award seeks to
define the epigenomic landscape of myeloid populations in order to differentiate HIV Associated
Neurocogntivie Disease (HAND) from Mild Cognitive Impairment state of Alzheimer’s Disease (MCI-AD) in
individuals living with HIV on suppressive antiretroviral therapy (ART). This diversity supplement will expand
the scope of research in Specific Aim 1 to include epigenetic signatures of cell free DNA (cfDNA) to further aid
in elucidating the pathogenesis of neurocognitive impairment observed in people living with HIV (PLWH) and
provide postdoctoral training in epigenetics and immunology in the pathogenesis of HAND. The goal of the
diversity supplement is for Dr. Pang to gain experience and preliminary data on epigenetic signatures in the
periphery specific to neurocognitive impairment to submit a K01 application in 2023.

## Key facts

- **NIH application ID:** 10632875
- **Project number:** 3R01AG063846-03S1
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** Lishomwa C Ndhlovu
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $63,017
- **Award type:** 3
- **Project period:** 2020-03-15 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10632875

## Citation

> US National Institutes of Health, RePORTER application 10632875, Harnessing single cell epigenome-wide profiling of myeloid cells to compare and contrast Alzheimer's from HIV-associated cognitive dysfunction (3R01AG063846-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10632875. Licensed CC0.

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