There is growing need for the conduct of national evaluations that will inform government agencies regarding the value of their programs and policies. In 2018 the Foundations for Evidence-Based Policymaking Act (aka: Evidence Act, P.L. 115-435) was enacted that requires Veterans Affairs (VA), and all other cabinet level agencies, to confirm that their budgets are justified and supported by evidence and evaluation. The Quality Enhancement Research Initiative (QUERI) program facilitates the implementation of the Evidence Act in VA by identifying high priority areas for which evaluation is needed to inform policies. The high demand for these evaluations has led to the call for QUERI evidence-based policy evaluation centers to address this growing need. The HSR&D Center of Innovation for Complex Chronic Care in Chicago is poised to conduct evaluations of high priority programs and policies through the establishment of the Evidence to Practice Evaluation Center for Veterans (EPEC-Vet). The EPEC-Vet will: 1) conduct rigorous evaluations of high priority programs and policies that support implementation and/or ongoing policies and practice, 2) disseminate findings to key operations partners and other stakeholders, decision makers, researchers and veterans using a multi-pronged strategy of dissemination that addresses the elements of the QUERI ACTION impact framework; and 3) be responsive to stakeholder needs through the operation of an evaluation center that is flexible and has the complement of expertise and experience. This is addressed through a team of co-investigators, experienced program staff, a contract with our affiliated university to provide additional methods experience, and a group of subject matter `experts on call' that are knowledgeable about several of the priority areas identified in the RFA. Our center's co-principal investigators, core leaders and co-investigators represent a seasoned group of health services and QUERI investigators and methodologists who have experience working with a variety of VA operations partners. To supplement our methodological needs, we will contract with our university affiliate using evaluation-specific task orders. EPEC-Vet will be led by two principal investigators (Weaver & Stroupe) who will oversee three cores: operations, methods and knowledge translation. An advisory panel will provide regular review and feedback on center progress and direction. We anticipate developing and executing at least two evaluations each year. Using a conceptual model modified from the Center for Disease Control's evaluation framework, supplemented with implementation frameworks, our evaluation work will involve a cyclical process of stakeholder engagement, development of evaluation plans, conduct of evaluations and dissemination of findings. Our evaluations will provide evidence needed to support or modify VHA policies and practices to provide the best outcomes for Veterans.