PROJECT SUMMARY/ABSTRACT In response to the NCI-funded P30 Cancer Center Support Grant opportunity, “Administrative Supplement for the P30 Cancer Center Support Grant to Enhance Sexual Orientation and Gender Identity (SOGI) Data Collection,” this proposed research will use the Quality Implementation Framework (QIF) to guide a multi-level SOGI data collection and utilization intervention at the University of New Mexico Comprehensive Cancer Center (UNMCCC). The National Academy of Science and the Society of Clinical Oncology call for SGM specific education and training, and culturally relevant service delivery for SGM persons at increased risk for, and with high incidence rates of, anal, breast, cervical, colorectal, endometrial, lung, prostate, and hormone related cancers. SGM individuals, along with racial, ethnic, rural and other minoritized populations, experience stigma and discrimination that may result in chronic stress that can compound cancer- related-stress, medical mistrust, and lead to poorer outcomes when compared to heterosexual, cisgender white counterparts. The UNMCCC is the only NCI-designated Comprehensive Cancer Center in a 500 mile radius, and will provide statewide cancer care to an estimated 28,800 of New Mexico’s 75,000 SGM residents who will likely develop cancer in their lifetimes. SGM persons have complex and intersecting identities existing within and across the State’s ethnically/racially (i.e. 49.1% Hispanic, 10.9% AI and 37.1% NHW, 2.6% black, 1.8% Asian) and geographically diverse populations. UNMCCC is also a nexus for twenty-five affiliate cancer care settings that form the New Mexico Cancer Research Alliance. In partnership with the Pacific Institute for Research and Evaluation and the National LGBT Cancer Network, the study team will use QIF to identify potential barriers to the systematic collection of patient SOGI data, incorporate National Academy of Science Engeneering Medicine recommended SOGI measures into UNMCCC Eelectronic Health Records for medical and research utilization, tailor staff/provider-cultural competency/cultural humility training interventions, and design patient-facing “We Ask Because We Care” campaigns to encourage welcoming and comfortable care for SGM patients and their families. An evaluation strategy using SMART objectives will be used to assess the developed intervention to measure the longitudinal adoption, reach, and fidelity of systematic collection and utilization of SOGI measures at UNMCCC, efficacy of staff and provider training, and SGM patient, caregiver and family satisfaction with the “We Ask Because We Care” campaign.