# Exploring influences of the socio-ecological environment on the Queen Club program for adolescent girls in Tanzania

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $24,518

## Abstract

SUMMARY
Adolescent girls and young women (AGYW; ages 15-24) in sub-Saharan Africa face the dual threats of HIV
infection and unintended pregnancy that severely undermine their long-term wellbeing. However, despite the
urgent need to reach AGYW with sexual and reproductive health (SRH) services, health systems are often ill
equipped to overcome the numerous barriers to health care services faced by AGYW. The goal of the study is
to evaluate Malkia Klabu (“Queen Club”) in Tanzania, a loyalty program intervention that creates AGYW-
friendly drug shops where AGYW can access HIV prevention services and contraception. The motivation for
this approach is the growing recognition that drug shops, which are widely distributed and vastly outnumber
health facilities, can promote beneficial health behaviors, bridge gaps in health services, and mitigate health
workforce shortages. Furthermore, although HIV testing is the gateway to HIV prevention and care, self-testing
with oral fluid has not been widely adopted by AGYW, despite government adoptions across the Region.
Based on promising data from a pilot study, we hypothesize that the creation of a welcoming environment
through the Malkia Klabu intervention will attract AGYW and bolster uptake of SRH services, including HIV
self-test (HIVST) kits and contraception, thereby increasing the proportion of AGYW who are aware of their
HIV status and empowered to avoid unintended pregnancy. We have designed an innovative, mixed-methods
study to evaluate the Malkia Klabu intervention, which was designed for and by AGYW to create AGYW-friendly
drug shops where HIVST is available alongside contraception and linkages to care. Specifically, our 5-year study
includes a cluster-randomized trial (C-RCT) in 40 health facility catchment areas to evaluate the intervention’s
effectiveness on HIV diagnoses and antenatal care registrations among AGYW at the population level (Aim 1).
We will then link these outcomes to individual-level behaviors (e.g., recent HIV testing, unmet for
contraception, linkage to care) and other demand-side pathways leading to impact with a RDS survey and
focus groups with AGYW (Aim 2). Finally, a mixed-methods, implementation science study will pinpoint supply-
side factors influencing effectiveness (e.g., implementation models, intervention fidelity, shop characteristics;
Aim 3). At the study’s conclusion, we will have rigorously evaluated Malkia Klabu, uncovered factors that
enhance program success, and described potential pathways of impact, consistent with an implementation
science approach to close the gap between evidence and practice. The research team is a collaboration
between the University of California (San Francisco and Berkeley), Health for a Prosperous Nation, the
Tanzania Ministry of Health, Community Development, Gender, Elderly, and Children, and the Tanzania
Pharmacy Council.
The proposed study will rigorously explore, for the first time, whether AGYW-friendly drug shops can be used
t...

## Key facts

- **NIH application ID:** 10642303
- **Project number:** 3R01MH124516-02S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Jenny Xin Liu
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $24,518
- **Award type:** 3
- **Project period:** 2022-11-10 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10642303

## Citation

> US National Institutes of Health, RePORTER application 10642303, Exploring influences of the socio-ecological environment on the Queen Club program for adolescent girls in Tanzania (3R01MH124516-02S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10642303. Licensed CC0.

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