Abstract: Administrative Core, University of California, Los Angeles This Program Project involves the active participation of researchers from 4 different institutions, each of them located in a distinct location (University of California, Los Angeles; Pasteur Institute; The Medical College of Wisconsin, and Duke University). The effective integration and communication of the different participants in this initiative is critical to achieve the aims. The primary goal of the Main Administrative Core (located at UCLA) is to facilitate communication and integrate Projects and Cores and manage administrative aspects needed for the smooth operation of the Program. Note that there is a separate International Clinical Administrative Core located at Duke University that is responsible for administrative aspects of international coordination, including data and sample management. The specific objectives of the Main Administrative Core are the following: 1) To promote integration, rapid communication and effective collaboration between the members of Projects and Cores; 2) To support exchange of information, reagents, methodologies, expertise and data among all members of the Program Project; 3) To implement and maintain an External Scientific Advisory Board that will be tasked to critically evaluate the progress of the Program; and 4) To manage all administrative and compliance functions associated with the Program Project. Integration of project and core members will be accomplished by organizing various types of meetings to increase interaction, exchange of information, re-prioritize strategy and communicate results through publications and reports. Four types of meetings will be implemented: 1) annual meetings of PIs and Co-PIs with the External Scientific Advisory Board; 2) quarterly meetings of all research personnel associated with all projects and cores to present progress through video-conference; 3) monthly meetings through videoconference of the management team to discuss status of the Program Project, resolve potential problems and overview the budget; and 4) bimonthly project meetings to discuss ongoing activities, problem solving, and planning. The integration of all program project personnel will be facilitated using the Microsoft Teams calendar, meeting, chat, and project management tools. An important task of the Administrative Core will be to make sure the Program Project is advancing in the accomplishment of the goals and timelines originally proposed, but also to incorporate new ideas and methodologies that may arise. This will be achieved with the help of the Scientific Advisory Board during the annual meeting where we will review and evaluate the scientific progress and re-prioritize effort if needed.