# International Clinical Administrative Core

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2023 · $322,351

## Abstract

Abstract: International Clinical Administrative Core, Duke University
Leptospirosis is a common worldwide zoonosis that disproportionately affects low resource areas. The ability to
readily and accurately discriminate leptospirosis infection from other acute febrile illness (AFI) is challenged by
non-specific clinical features and absence of diagnostic tools for point-of care diagnosis. This P01 program will
investigate pathogen-host interactions and develop new diagnostic tests to improve leptospirosis detection
based on host immune and molecular response patterns to non-severe and severe infection. This work is on a
translational pathway towards the ultimate goal of rapid, low-cost AFI diagnostic platforms appropriate for low
resource settings and deployable at the point-of-care. To achieve the program objectives, the proposed
International Clinical Administrative Core (Clinical Core) will serve a coordinating center function to provide
comprehensive, centralized administrative and clinical support to 3 global field sites in Sri Lanka (Galle),
Nicaragua (Leon), and Tanzania (Moshi), as well as to facilitate interactions between international and domestic
partnering institutions including between the Pasteur Institute (Paris, France) and other program projects. The
Clinical Core comprises an experienced, interdisciplinary team that will leverage already existing administrative
and clinical infrastructure to manage the Core’s 3 specific aims including 1) to establish sharing agreements with
international sites and program projects and provide administrative support for site activities; 2) to establish an
integrated clinical data- and bio-repository resource to support all program projects; and 3) to facilitate
operational activities at international field sites to assure robust study enrollment, collection of specimens and
data, reference standard testing, and etiology and disease severity determination. The International Clinical
Administrative Core will be located within the Duke Global Health Institute’s Hubert-Yeargan Center (HYC) for
Global Health. The Clinical Core will be led administratively by HYC Executive Director Christopher Woods, MD,
MPH (Core Co-Lead, Administrative Lead) and scientifically by Megan E. Reller, MD, PhD, MPH (Core Co-Lead,
Diagnostic Lead).

## Key facts

- **NIH application ID:** 10643288
- **Project number:** 1P01AI168148-01A1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Megan Elizabeth Reller
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $322,351
- **Award type:** 1
- **Project period:** 2023-05-16 → 2028-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10643288

## Citation

> US National Institutes of Health, RePORTER application 10643288, International Clinical Administrative Core (1P01AI168148-01A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10643288. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*