# Mobile app delivered Mentalizing Imagery Therapy to augment remote family dementia caregiver skills training: a pilot randomized, controlled trial with outcomes assessment using digital phenotyping

> **NIH NIH K76** · MASSACHUSETTS GENERAL HOSPITAL · 2022 · $251,250

## Abstract

Project Summary / Abstract
 Over 15 million Americans serve as family caregivers of relatives with Alzheimer’s disease (AD) and AD-
related dementias (ADRD). Family caregivers often experience high levels of stress and burden, resulting in
poor mental health and increased risk of physical illness. The National Institute on Aging Strategic Plan
identifies as a crucial priority area the need to develop better interventions to improve the mental and physical
health of family ADRD caregivers. The purpose of this administrative supplement is to support the research
training of Dr. Felipe Jain, a psychiatrist at Harvard Medical School. Dr. Jain is a recipient of the Paul B.
Beeson K76 Emerging Leaders in Aging Research Career Development Award for his research to reduce family
ADRD caregiver stress and burden using mobile application tools (mentalizing imagery therapy practices,
mindfulness exercises and caregiver skills education).
 Usage of educational and psychotherapeutic mobile applications (Apps) by caregivers shows a
significant drop-off in engagement over the course of weeks, a similar pattern to that of mobile psychotherapy
App usage by the general population. The NIH Science of Behavior Change initiative aims to study
mechanisms that promote long-term adoption of healthy behaviors, such as engagement with stress reduction
and caregiver skills tools. A focus group study conducted by Dr. Jain with English and Spanish speaking
caregivers found that caregivers believed that asynchronous chat groups with peers guided by an expert
facilitator would substantially improve caregiver support and increase mobile App engagement.
 This supplement proposal will evaluate whether integration of a new facilitated chat room feature into a
mobile App with caregiver tools improves family ADRD caregiver support and promotes long-term
engagement. The study will characterize features that optimize usage of the mobile App chatroom. Based on
habit formation and motivation theory, it is hypothesized that chatroom participation will increase long-
engagement with other healthful mobile App tools. To improve efficiency and reduce time to facilitator
response for urgent chat posts (such as those reflecting dangerous symptoms of aggression in the person living
with dementia, or severe psychological symptoms in the caregiver such as thoughts of self-harm), a natural
language processing algorithm will be developed that may ultimately send a rapid alert to the facilitator. The
proposed research will test a novel strategy for behavior change that improves psychosocial support for family
ADRD caregivers, provides opportunities for expert guidance, and promotes stress reduction and caregiver
skills education.

## Key facts

- **NIH application ID:** 10643652
- **Project number:** 3K76AG064390-03S1
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Felipe A. Jain
- **Activity code:** K76 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $251,250
- **Award type:** 3
- **Project period:** 2020-09-15 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10643652

## Citation

> US National Institutes of Health, RePORTER application 10643652, Mobile app delivered Mentalizing Imagery Therapy to augment remote family dementia caregiver skills training: a pilot randomized, controlled trial with outcomes assessment using digital phenotyping (3K76AG064390-03S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10643652. Licensed CC0.

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