# Disease Modeling Core

> **NIH NIH P30** · UNIVERSITY OF COLORADO DENVER · 2023 · $173,857

## Abstract

DISEASE MODELING CORE 
PROJECT SUMMARY/ABSTRACT 
The overall mission of the Disease Modeling Core (DM core) is to provide diabetes researchers with access to 
novel human stem cell-derived in vitro cell models for investigating cellular and molecular features of both Type 
1 and Type 2 diabetes. Recent progress in stem cell, organoid culture, gene editing and directed differentiation 
technologies has afforded opportunities to develop state-of-the-art pre-clinical human models. However, 
because of the complex experimental protocols and specialized reagents used, together with the considerable 
up-front costs and time required to develop these sophisticated stem cell-based models, it is not practical nor 
cost-effective to develop these models in individual laboratories. The goal of DM core is to provide the expertise, 
infrastructure and access to novel human model systems and technologies to DRC investigators. To help 
overcome the obstacles faced by basic scientists and clinical researchers who wish to establish human stem cell 
approaches in their laboratories, we will provide expertise, resources and training in start-of-the-art stem cell 
technologies together with rigorous quality control testing, validation standardization and authentication all model 
platforms and reagents. This goal will be achieved in three ways: 1) providing access and training in current and 
emerging pluripotent and adult stem cell technologies for in vitro human disease modeling, including the use of 
organoids; 2) providing access, training and implementation of genome editing technology, directed cell 
differentiation/programming, and gene expression systems; and 3) providing validation, authentication and data 
sharing of all DM-related technologies. Thus, the overall mission of this core is to facilitate access, generation 
and usage of novel human stem cell-derived in vitro models to promote basic and translational innovative 
diabetes research at UC AMC.

## Key facts

- **NIH application ID:** 10646158
- **Project number:** 5P30DK116073-04
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Holger A. Russ
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $173,857
- **Award type:** 5
- **Project period:** 2020-04-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10646158

## Citation

> US National Institutes of Health, RePORTER application 10646158, Disease Modeling Core (5P30DK116073-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10646158. Licensed CC0.

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