# Center for the Translational Neuroscience of Alcoholism

> **NIH NIH P50** · YALE UNIVERSITY · 2023 · $1,741,341

## Abstract

CTNA Overall
John Krystal, M.D.
Abstract
The gap between basic research advances and new clinical insights and treatments remains a
critical obstacle to progress in the field of alcoholism research. This translational neuroscience
mission is the enduring focus of the Center for the Translational Neuroscience of Alcoholism
(CTNA). CTNA conducts groundbreaking molecular neuroscience, molecular genetics,
functional and chemical neuroimaging, and psychopharmacology studies in the service of
providing new insights to bridge the gap between basic and clinical research. This renewal
application will study how inhibition of mGluR5 might normalize disturbances in cortico-striatal
glutamate signaling arising from upregulation of NMDA-R and, in so doing, attenuate both goal-
oriented (model-based learning) and habitual (model-free learning) alcohol consumption in
animals and reduce alcohol consumption in human heavy drinkers. In so doing, we propose the
first translational neuroscience evaluation of the therapeutic potential of mGluR5 NAM’s, a
mechanism that has received intensive preclinical study. Building upon its prior achievements,
The CTNA will facilitate transdisciplinary research within projects and across projects and with
other alcohol focused initiatives nationally. It will also continue its highly productive Pilot Projects
Core that provides an open competitive mechanism to enable the Center to rapidly encompass
innovative new research and to engage outstanding investigators new to alcoholism research.
CTNA will continue to expand its educational mission, building on the success of the the
International Conference on the Applications of Neuroimaging to Alcoholism.

## Key facts

- **NIH application ID:** 10646261
- **Project number:** 5P50AA012870-23
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** John H. Krystal
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $1,741,341
- **Award type:** 5
- **Project period:** 2001-06-04 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10646261

## Citation

> US National Institutes of Health, RePORTER application 10646261, Center for the Translational Neuroscience of Alcoholism (5P50AA012870-23). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10646261. Licensed CC0.

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