# Miami Dade County ASsessment of Phylogenetics to Improve Resource Equity: MD ASPIRE

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2023 · $960,731

## Abstract

ABSTRACT
The Ending the HIV Epidemic (EHE) Initiative boldly aims to reduce HIV incidence in high burden areas by 90%
by 2030, yet challenges remain in measuring incidence to identify priority populations and knowing how to best
allocate local resources. To date, HIV molecular surveillance-based interventions have not been linked to a
reduction in HIV incidence. That is (with rare exception), public health efforts directed to individuals associated
with rapidly growing HIV transmission clusters have not been shown to reduce the number of new HIV infections
or the proportion of people virally suppressed in the regions or groups where these services were delivered.
There are no existing resource allocation models that are informed by local molecular and HIV program data to
determine how to best allocate resources relevant to EHE targets. The “Los Angeles County ASsessment of
Phylodynamics to Improve Resource Equity (LAC ASPIRE)” team will use i) advanced phylodynamic
approaches and prospective measures of incidence to identify populations with the highest transmission rates
in Los Angeles County (LAC) and ii) economic modeling to optimize allocation of public health program resources
to achieve EHE and other stakeholder targets. The ASPIRE team is a partnership between investigators at
several academic universities and the LAC Division of HIV and STD Programs (DHSP). Analyses will use coded
and de-identified HIV surveillance data and program data provided by the LAC DHSP. The proposed study will
identify LAC populations with the highest transmission rates and denote as priority populations. We will use
economic modeling to develop strategies that optimize the allocation of prevention resources to i) reduce HIV
incidence, ii) improve HIV-related health outcomes, and iii) improve equity across populations. We will engage
stakeholders—defined as 1) LAC DHSP personnel, 2) those directly or indirectly involved in administering HIV
Programs in LAC, and 3) persons with HIV (PWH) and other key affected populations—to provide guidance on
population and resource prioritization strategies that are both regionally acceptable and most likely to achieve
EHE targets.
The overall study objective is to develop a process to guide decision-making related to allocation of HIV program
resources by public health departments informed by regional program and transmission data. Project specific
aims include: Aim 1 (IDENTIFY). Identify populations that are the highest priority for HIV prevention efforts (these
data will inform the epidemic model used in Aim 2); Aim 2 (ALLOCATE). Develop a user-friendly dynamic
transmission model that will project the impact of alternative strategies for the optimal allocation of resources to
LAC HIV prevention programs (these data will project health outcomes and cost-effectiveness); and Aim 3
(ENGAGE). Engage key stakeholders to develop a process to guide project outcomes and build capacity at the
LAC Health Department for data analysis th...

## Key facts

- **NIH application ID:** 10653972
- **Project number:** 5R01MH132151-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** SUSAN JANET LITTLE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $960,731
- **Award type:** 5
- **Project period:** 2022-07-01 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10653972

## Citation

> US National Institutes of Health, RePORTER application 10653972, Miami Dade County ASsessment of Phylogenetics to Improve Resource Equity: MD ASPIRE (5R01MH132151-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10653972. Licensed CC0.

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