# Proteomic Profiling of Cardiac Dysfunction in the MACS-WIHS Combined Cohort Study."

> **NIH NIH U01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2022 · $70,715

## Abstract

Abstract
Fund Year 2023 OAR Strategic Funds are requested to perform high-throughput proteomic
measurements to investigate the protein signatures of cardiac dysfunction and its progression in
MWCCS. Previously collected blood specimens in participants who completed baseline
echocardiography in MACS Visits 67-71 (n=1195) and WIHS Visits 44-50 (n=1655) will be used
to measure proteomics in order to permit discovery of protein markers. Genotypic data in MACS
and WIHS will be leveraged to conduct Mendelian randomization analysis using protein
quantitative trait loci, allowing causal inference and selection of protein targets for
pharmacotherapy. This supplement will support HIV/AIDS research corresponding to the
following NIH high-priority AIDS-designated topics: (1) HIV-associated comorbidities; (2) cross-
cutting areas involving clinical translational research, cardiovascular disease, proteomics, multi-
omics, and health disparities; and (3) training of the next generation of HIV investigators in
omics and comorbidities research.

## Key facts

- **NIH application ID:** 10654914
- **Project number:** 3U01HL146204-04S3
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Kathryn M. Anastos
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $70,715
- **Award type:** 3
- **Project period:** 2019-04-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10654914

## Citation

> US National Institutes of Health, RePORTER application 10654914, Proteomic Profiling of Cardiac Dysfunction in the MACS-WIHS Combined Cohort Study." (3U01HL146204-04S3). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10654914. Licensed CC0.

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