# Clinical Trials Network New England Consortium Node: Admin Supplement CTN0126

> **NIH NIH UG1** · YALE UNIVERSITY · 2022 · $688,344

## Abstract

Project Summary/Abstract
The United States continues to be faced with an ongoing public health crisis of drug overdose and other drug-
related harms. In 2020 there were more than 100,000 overdose deaths, with more than half due to synthetic
opioids such as fentanyl. Despite significant public health attention toward the opioid crisis in the US, these
harms continue to grow and to have tremendous impacts on individuals, families and communities. Among the
challenges in addressing the opioid crisis is that it continues to evolve, with changes in the drug supply,
available treatment, the populations affected, and public perceptions. Long-term data on the course of opioid
use disorder (OUD), individual differences in prognosis, the long-term effects of treatment, and markers of
recovery are urgently needed to inform public health interventions, treatment implementation, and novel
treatment development. The overarching objective of this project is to conduct a long-term follow-up of two
large National Institutes on Drug Addition (NIDA) Clinical Trial Network (CTN) clinical trials funded through the
National Institutes of Health (NIH) Helping End Addiction Long-term (HEAL) Initiative to begin to fill these
important gaps in knowledge. This protocol focuses on the first stage, a longitudinal follow-up study that will
collect yearly outcomes data for an initial 4-year study period on adults with opioid use disorder (OUD). This
longitudinal, observational study will entail annual phone assessments of domains of interest (e.g., substance
use, treatment engagement) as well as monthly assessments that are distributed via SMS and email to be
completed electronically by the participant. This first stage aims to characterize the long-term course of OUD
and to create a repository of outcomes data that will be used for future concept development and analysis of
studies within the CTN that evaluate the long-term course and recovery of OUD. In the second stage, the study
aims to expand data collection to additional populations of interest, including from other CTN studies.

## Key facts

- **NIH application ID:** 10655828
- **Project number:** 3UG1DA015831-21S4
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Gail D'Onofrio
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $688,344
- **Award type:** 3
- **Project period:** 2022-07-01 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10655828

## Citation

> US National Institutes of Health, RePORTER application 10655828, Clinical Trials Network New England Consortium Node: Admin Supplement CTN0126 (3UG1DA015831-21S4). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10655828. Licensed CC0.

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