# Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes

> **NIH NIH R21** · DUKE UNIVERSITY · 2022 · $160,253

## Abstract

Abstract
Exercise training produces substantial health benefits, summarized in the Physical Activity Guidelines Advisory
Committee Report and incorporated into the 2008 and 2018 Physical Activity Guidelines for Americans.
Despite the well-known benefits, too few individuals adopt exercise as a health maintenance strategy. Thus,
determining whether a relatively modest duration of exercise training in middle age can lead to sustained
health benefits as individuals progress into older age groups (legacy effects) is of public health and clinical
importance. As the parent R21 seeks to determine whether a relatively short six-month exercise intervention
(STRRIDE-PD) produces sustained, legacy health effects ten years later, this proposed supplement will
simultaneously investigate in a community-based cohort (UNC Alumni Heart Study; UNCAHS) whether self-
directed exercise behavior is also related to long-term health status. Thus, the proposed supplement will
enhance the significance of the parent R21 by extending the generalizability of the findings to individuals who
would not have qualified for the STRRIDE studies due to either their risk factor or medical history status.
Matched to the STRRIDE-PD Reunion cohort, 200 age- and gender-matched participants from the UNCAHS
who have reported on their unsupervised exercise behavior will be invited to complete parallel assessments of
cardiorespiratory fitness and cardiometabolic risk factors. Integrating the UNCAHS via the supplement will
allow us to compare the legacy effects of supervised exercise training programs to self-directed exercise in a
community-based cohort. Taken together, the parent R21 and the proposed supplement will provide unique
insight into the biological and psychological underpinnings of physical activity behavior in midlife and long-term
cardiometabolic health status.

## Key facts

- **NIH application ID:** 10656111
- **Project number:** 3R21AG075379-01S1
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** WILLIAM E KRAUS
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $160,253
- **Award type:** 3
- **Project period:** 2022-02-01 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10656111

## Citation

> US National Institutes of Health, RePORTER application 10656111, Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes (3R21AG075379-01S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10656111. Licensed CC0.

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