# Asymmetric Synthesis via Organoboron Compounds

> **NIH NIH R35** · AUBURN UNIVERSITY AT AUBURN · 2023 · $276,713

## Abstract

Project Summary
 Chiral, nonracemic molecules are highly important in the areas of organic synthesis, material
science and chemical biology. They are also of great value to agrochemical and pharmaceutical
industries because the three-dimensional structures of chiral molecules allow for the access to
broader chemical space in drug discovery. Therefore, the development of catalytic methods that
enable the generation of chiral molecules with high enantiopurity is important not only to academic
research, but also to pharmaceutical industries, and to human health.
 Organoboron compounds are useful building blocks in organic synthesis. The boryl group is
amenable to a variety of stereospecific chemical transformations. More importantly, the vacant p-
orbital of the boron atom can stabilize an anion or a radical in the neighboring carbon atom. This
unique property has facilitated the emergence of many innovative catalytic processes to generate
enantioenriched organoboronates. In this regards, our group has established a research program
centered on asymmetric synthesis using organoboron compounds. We particularly aim to address
the challenges in enantioselective synthesis of chiral molecules that are difficult to access by
conventional methods. In this proposal, we seek to develop catalytic asymmetric transformations
using organoboron compounds by exploiting the novel reactivities of α-boryl metal complexes and
α-boryl radicals. Through our continued collaboration with experts in computational chemistry, we
will further our understanding of the reaction mechanisms, which will guide us in the direction of
transformative reaction design. Meanwhile, the studies will allow for the access to enantioenriched
molecules that are valuable for organic synthesis and relevant to drug discovery.

## Key facts

- **NIH application ID:** 10656577
- **Project number:** 5R35GM147523-02
- **Recipient organization:** AUBURN UNIVERSITY AT AUBURN
- **Principal Investigator:** Ming Chen
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $276,713
- **Award type:** 5
- **Project period:** 2022-07-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10656577

## Citation

> US National Institutes of Health, RePORTER application 10656577, Asymmetric Synthesis via Organoboron Compounds (5R35GM147523-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10656577. Licensed CC0.

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