# Lipidomics in Acute Ischemic Stroke: Relationship to Symptoms and Outcomes

> **NIH NIH K23** · UNIVERSITY OF ILLINOIS AT CHICAGO · 2023 · $176,077

## Abstract

PROJECT SUMMARY/ABSTRACT
 The purpose of this K23 Mentored Patient-Oriented Career Development Award is to provide the
necessary mentorship, knowledge, and training to Dr. Sarah Martha, a post-doctoral fellow at the University of
Washington School of Nursing. The long-term goal of Dr. Martha is to independently develop and lead an
extramurally-funded program of research focused on targeted interventions to improve symptoms and
outcomes in acute ischemic stroke survivors. Acute ischemic stroke (AIS) is the leading cause of severe long-
term disability in the US. AIS is characterized by the disruption of cerebral blood flow due to large arterial
occlusion, caused by a cerebral thrombus. Half of AIS survivors exhibit fatigue and depressive symptoms,
cognitive deficits, and poorer functional and health-related quality of life (HRQOL) outcomes. Recent advances
in omics methodology enables lipidomic profiling, which may provide knowledge of the underlying pathology of
AIS and its associated symptoms and outcomes. This proposed research will address a gap in knowledge in
the relationship between lipid biomarkers, development of symptoms and outcomes in the 6 months following
AIS and the role of reperfusion intervention. This career development award will support the applicants training
and research goals through the provision of mentorship, coursework, laboratory training, and other activities
directly relevant to the content areas of advanced statistical methods for longitudinal clinical research, analysis
of lipidomic biomarkers, AIS pathology, clinical trial design, and career development. The project proposed in
this application will examine how and when lipidomic signatures, symptoms, functional and HRQOL outcomes
change after AIS, and what influence, if any, reperfusion interventions have on these changes. The applicant
proposes a prospective cohort (2 groups, n=52/each), longitudinal study involving participants following AIS.
The research project proposed in the application will analyze arterial and peripheral plasma lipid biomarkers
that may provide lipidomic signatures useful in identifying predictive symptoms and cognitive, functional, and
HRQOL outcomes. Specifically, the proposal aims are to: 1) Compare symptoms (fatigue and depressive),
cognitive, functional, and HRQOL outcomes over 6 months between AIS patients who did and did not receive
reperfusion intervention; 2) Compare peripheral plasma lipid levels over 6 months between AIS patients who
did and did not receive reperfusion intervention; 3) Examine early and late peripheral plasma lipid levels and
symptoms, cognitive, functional, and HRQOL outcomes over time in patients who do and do not receive
reperfusion intervention; 4) Explore the relationships of 13 lipid classes with symptoms, cognitive, functional,
and HRQOL outcomes over 6 months in (4a) distal and proximal arterial plasma lipid levels in reperfusion
intervention group (4b/c) peripheral plasma lipid levels in AIS patients (4...

## Key facts

- **NIH application ID:** 10656586
- **Project number:** 5K23NR019864-04
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT CHICAGO
- **Principal Investigator:** Sarah R Martha
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $176,077
- **Award type:** 5
- **Project period:** 2021-07-30 → 2024-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10656586

## Citation

> US National Institutes of Health, RePORTER application 10656586, Lipidomics in Acute Ischemic Stroke: Relationship to Symptoms and Outcomes (5K23NR019864-04). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/10656586. Licensed CC0.

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