# Supplement for MINI point-of-use device

> **NIH NIH U01** · UNIVERSITY OF MIAMI CORAL GABLES · 2022 · $170,248

## Abstract

Abstract
We propose portable, proven, point of care/surveillance devices for use in SARS-CoV-2 testing that
expands upon the TINY (Tiny Isothermal Nucleic acid quantification sYstem) , which is called the
MINI. These devices leverage LAMP (loop mediated isothermal amplification) technology developed by
the Mason Lab in collaboration with technological developments from the Erickson lab to test up to 96
samples in real time. These devices can operate in areas without existing medical infrastructure with
portability and high throughput, filling an existing gap in the current SARS-CoV-2 testing infrastructure.
We also envision these devices as filling a necessary gap in COVID-19 surveillance, leveraging pilot
studies in detecting SARS-CoV-2 and other viruses in sewage to monitor the evolution of the pandemic
in the coming years and building an infrastructure to better monitor and predict future viral outbreaks.
A 96 well version of our existing TINY detection device, called the MINI, will be deployed at large scale to
develop surveillance and point of care testing for SARS-CoV-2 in wastewater, saliva, and other
samples. This technology is accompanied by an easy to use software package for exporting and
preserving results that can be installed on any computer. This technology is able to screen the most
prevalent circulating COVID-19 variants by targeting the viral envelope gene (E) and RNAse P (RP) gene.
These methods can help with the current COVID-19 outbreak and aid in future risk management and
pathogen mapping.

## Key facts

- **NIH application ID:** 10656815
- **Project number:** 3U01DA053941-02S1
- **Recipient organization:** UNIVERSITY OF MIAMI CORAL GABLES
- **Principal Investigator:** Christopher Edward Mason
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $170,248
- **Award type:** 3
- **Project period:** 2022-07-01 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10656815

## Citation

> US National Institutes of Health, RePORTER application 10656815, Supplement for MINI point-of-use device (3U01DA053941-02S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10656815. Licensed CC0.

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