# Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosis

> **NIH NIH U01** · JOHNS HOPKINS UNIVERSITY · 2022 · $11,716

## Abstract

MACS/WIHS Combined Cohort Study (MWCCS) Administrative Supplement:
Abstract. While significant recent changes in the clinical care of people with HIV (PWH) (e.g.,
universal ART initiation, greater use of statins as prophylaxis) have reduced cardiovascular
disease (CVD) risk, concurrent developments that may increase CVD risk (e.g., shift to
integrase inhibitors as first-line HIV treatment, continued aging of the HIV population) mean that
the determinants of CVD in PWH are ever-changing. We have the opportunity to extend our
existing MWCCS database of -omics measures in women in relation to HIV-associated CVD to
men, and expand the scope with additional assessments of the microbiome, metabolome, and
sex hormones. We propose to use archived specimens to measure gut microbiota and selected
microbiome-related metabolites and immune marker panels, including markers of immune
activation, gut barrier dysfunction and microbial translocation in relation to carotid
atherosclerosis in MWCCS men, and assess both the independent and mediating roles of sex
hormones in this relationship among both women and men with HIV. Our aims support
HIV/AIDS research that falls under the following NIH high priority AIDS-designated topics: 1)
immune dysfunction, persistent inflammation, and microbiome and genetic determinants that
underpin the development of high priority HIV co-morbidities, and 2) long-term treatment or
prevention strategies for HIV-relevant comorbid conditions across the lifespan.

## Key facts

- **NIH application ID:** 10656874
- **Project number:** 3U01HL146193-04S2
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Gypsyamber D'Souza
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $11,716
- **Award type:** 3
- **Project period:** 2019-04-09 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10656874

## Citation

> US National Institutes of Health, RePORTER application 10656874, Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosis (3U01HL146193-04S2). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10656874. Licensed CC0.

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