# Utilizing All of Us data to examine the impact of COVID-19 on mental health among people living with HIV

> **NIH NIH R01** · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2022 · $107,340

## Abstract

Abstract
In response to the NOSI (NOT-PM-22-002), we propose to expand the resilience conceptual framework in
our parent grant (1R01MH127961-01A1, 12/2021-11/2026) to a different context (COVID-19) and a new
population (people living with HIV [PLWH] in the United States). Further, we propose to explore if a resilience
approach can be used to mitigate the negative impacts of COVID-19 on the mental health among PLWH. We
will leverage multiple datasets from the All of Us program, including electronic health records (EHR), a series
of COVID-19 Participant Experience (COPE) surveys, and other self-reported survey data. Integrating these
data from about 12 thousand PLWH who participated in COPE, we will: 1) examine the trends and patterns of
mental health outcomes (i.e., psychiatric disorder diagnoses via ICD-10 and mental health assessments via
survey) among PLWH before and after the COVID-19 outbreak; and 2) identify protective factors at multiple
socioecological levels including the individual level (e.g., resilience), interpersonal level (e.g., social support),
and health institutional level (e.g., health service accessibility) that may mitigate the negative impacts of the
COVID-19 pandemic on mental health outcomes among PLWH, especially the subgroups with socially
disadvantaged status (low income and low education) and stigmatized identities (racial/ethnic minorities,
sexual and gender minorities). Based on rich data from a large cohort of PLWH, the findings will advance our
understanding of their mental health needs during the pandemic and mental health disparities of PLWH in the
US and inform tailored health interventions to improve mental health outcomes among PLWH, especially
those from disadvantaged subgroups. Our study goal is aligned with the Office of AIDS Research's and National
Institute of Mental Health's research priorities in terms of social sciences studies and health disparities
reduction. The proposed study will leverage existing NIH investment, capitalize on a rapid understanding of
mental health needs among PLWH, stimulate additional collaborations with the All of Us program, and
promote the translation of All of Us data to public health implications. The experience and preliminary data
obtained from this supplement will position us for further efforts in utilizing All of Us data to improve mental
and other health outcomes of PLWH in the US.

## Key facts

- **NIH application ID:** 10657875
- **Project number:** 3R01MH127961-01A1S1
- **Recipient organization:** UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
- **Principal Investigator:** Xiaoming Li
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $107,340
- **Award type:** 3
- **Project period:** 2022-08-16 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10657875

## Citation

> US National Institutes of Health, RePORTER application 10657875, Utilizing All of Us data to examine the impact of COVID-19 on mental health among people living with HIV (3R01MH127961-01A1S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10657875. Licensed CC0.

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