# Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center

> **NIH NIH U01** · JOHNS HOPKINS UNIVERSITY · 2022 · $38,884

## Abstract

Abstract
Fund Year 2023 OAR Strategic Funds are requested to perform high-throughput proteomic
measurements to investigate the protein signatures of cardiac dysfunction in MWCCS.
Previously collected blood specimens in participants who completed baseline echocardiography
in MACS Visits 67-71 (n=1195) and WIHS Visits 44-50 (n=1655) will be used to measure
proteomics in order to permit discovery of protein markers. Genotypic data in MACS and WIHS
will be leveraged to conduct Mendelian randomization analysis using protein quantitative trait
loci, allowing causal inference and selection of protein targets for pharmacotherapy. This
supplement will support HIV/AIDS research corresponding to the following NIH high-priority
AIDS-designated topics: (1) HIV-associated comorbidities; (2) cross-cutting areas involving
clinical translational research, cardiovascular disease, proteomics, multi-omics, and health
disparities; and (3) training of the next generation of HIV investigators in omics and
comorbidities research.

## Key facts

- **NIH application ID:** 10658086
- **Project number:** 3U01HL146201-04S1
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** TODD T BROWN
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $38,884
- **Award type:** 3
- **Project period:** 2019-04-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10658086

## Citation

> US National Institutes of Health, RePORTER application 10658086, Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center (3U01HL146201-04S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10658086. Licensed CC0.

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