# MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS) - OAR Sleep Supplement

> **NIH NIH U01** · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · 2022 · $700,141

## Abstract

ABSTRACT
The objective of this supplement application is to investigate targeted kynurenine (KYN) pathway metabolites
as molecular mechanisms by which objectively measured habitual sleep and circadian disruption increase risk
for HIV-associated cardiometabolic disease and to determine whether these relationships differ by biological
sex and HIV disease status. We will measure targeted KYN pathway metabolites in stored plasma (n=800)
from well characterized MACS/WIHS Combined Cohort Study (MWCCS) men who already have habitual sleep
measures collected, validated, and systematically scored via one week continuous wrist actigraphy (Philips
Respironics Actiwatch Spectrum Plus). There will be no MWCCS participant and field staff burden for this
supplement. No study to date has examined KYN pathway activation as a mechanism linking sleep and
circadian disruption to HIV-related and inflammatory mediated comorbidities such as cardiometabolic disease
in a mixed sex sample nor has this been accomplished with representation across all HIV disease status
groups (well and poorly controlled HIV with comparison to uninfected controls). Results will provide novel
insights into biological sex and HIV disease status differences in the mechanistic relationships between sleep
and circadian disruption, KYN pathway activation, and HIV-associated cardiometabolic disease and provide a
strong foundation upon which to test targeted sleep and circadian interventions to reduce risk for HIV-
associated comorbidities in men and women aging with HIV.

## Key facts

- **NIH application ID:** 10658775
- **Project number:** 3U01HL146245-04S1
- **Recipient organization:** HEKTOEN INSTITUTE FOR MEDICAL RESEARCH
- **Principal Investigator:** Mardge H Cohen
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $700,141
- **Award type:** 3
- **Project period:** 2019-04-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10658775

## Citation

> US National Institutes of Health, RePORTER application 10658775, MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS) - OAR Sleep Supplement (3U01HL146245-04S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10658775. Licensed CC0.

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