# Light-Induced Atroposelective N-Heterocyclization via Chiral Perovskite Nanocrystals

> **NIH NIH R35** · SAN DIEGO STATE UNIVERSITY · 2023 · $376,250

## Abstract

Project Summary and Abstract
Novel method for constructing axially chiral N-heterocyclic molecules can have a
significant impact on the manufacture of pharmaceutical-active compounds and other
useful organic complexes. Our research program will develop a visible light induced
catalytic reaction approach that leads to the direct formation of chiral N-heterocycles that
were otherwise challenging to produce. The approach uses chiral semiconductor
perovskite materials as the catalyst which are directly derived from well-explored solar
cell materials that are bench-top achievable and economical to produce. In the proposed
strategy, organic substrates approach perovskite’s chiral surface for charge transfer,
leading to the key step for discriminate chiral configuration and thereby resulting in a
direct light-induced asymmetric ring-closure reaction. The unprecedented reaction
strategy described here is among the first of its kind, has the potential to introduce a wide
range of new asymmetric reactions for important axially chiral bio-relevant compounds,
and may be considered reliable linchpin reactions suitable for pharmaceutical synthesis.

## Key facts

- **NIH application ID:** 10659050
- **Project number:** 5R35GM147260-02
- **Recipient organization:** SAN DIEGO STATE UNIVERSITY
- **Principal Investigator:** Yong Yan
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $376,250
- **Award type:** 5
- **Project period:** 2022-08-01 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10659050

## Citation

> US National Institutes of Health, RePORTER application 10659050, Light-Induced Atroposelective N-Heterocyclization via Chiral Perovskite Nanocrystals (5R35GM147260-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10659050. Licensed CC0.

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