The HBNU Fogarty Global Health Training Program (the HBNU Program) fosters the next generation of global health scientists and enhance research capacity in low- and middle-income countries (LMICs) through a rigorous mentored research training plan for trainees early in their career. Specifically, it aims to support trainee research focused on reducing the mortality and morbidity associated with: HIV/AIDS and associated co-infections; noncommunicable diseases (NCDs) including cardiovascular disease, diabetes, and cancer; mental health; and maternal and child health and nutrition (MCHN). In addition to mentored research, training will include didactic components to develop competency in rigorous research design and methods, evaluation and analytic capacity, regulatory issues, and cross-cultural collaboration. The Program brings together leading academic research institutions with longstanding relationships in LMICs in a variety of disciplines and with multidisciplinary research capacities. The inclusion of institutions that have shown a historical commitment to educating students from groups underrepresented in biomedical research is prioritized. The four U.S. academic research institutions that will anchor our consortium are: Harvard University (Harvard T. H. Chan School of Public Health); Boston University (School of Public Health); Northwestern University (Institute for Global Health, Feinberg School of Medicine); and the University of New Mexico (School of Medicine, Center for Global Health). Our consortium’s partner LMIC research sites are 18 well-qualified institutions in 14 LMICs. These sites have strong pre-existing relationships with the Program’s principal investigators and institutions and have demonstrated capacity to provide outstanding mentored experiences. Specific Aims include: AIM 1: Recruit a diverse pool of qualified U.S. predoctoral and U.S. and LMICS postdoctoral applicants; including at least 17 trainees per year for Years 1-2 and 16 trainees per year for Years 3-5, for a minimum of 82 trainees over the award period; AIM 2: Deliver a comprehensive education and research support program, including Field Preparedness Training, Monthly Seminars, and U.S. based training for LMIC trainees, that will combine in-person and online learning and access to collaboration tools to support trainee individual professional development and research project implementation; AIM 3: Provide trainees with rigorous mentored research experiences at LMIC research sites with a very strong track record of peer-reviewed publications and NIH research outputs; AIM 4: Build LMIC and global health research capacity at consortium member institutions and internationally through activities such as alumni mentors and the Mentor Symposium. Ultimately, the Program will prepare a future generation of leaders to tackle and solve the most challenging global health problems through early investment in committed predoctoral and postdoctoral trainees to foster scient...